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中华妇幼临床医学杂志(电子版) ›› 2014, Vol. 10 ›› Issue (06) : 807 -810. doi: 10.3877/cma.j.issn.1673-5250.2014.06.025

所属专题: 文献

综述

早产儿产房复苏用氧的相关问题
李晋辉1   
  1. 1. 610041 成都,四川大学华西第二医院新生儿科
  • 收稿日期:2014-10-03 修回日期:2014-11-11 出版日期:2014-12-01

Issues Related to Oxygen Used in the Resuscitation of Preterm Infants in Delivery Room

Jinhui Li1   

  1. 1. Department of Neonatology, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2014-10-03 Revised:2014-11-11 Published:2014-12-01
  • About author:
    (Corresponding author : Wu Jinlin, Email : )
引用本文:

李晋辉. 早产儿产房复苏用氧的相关问题[J/OL]. 中华妇幼临床医学杂志(电子版), 2014, 10(06): 807-810.

Jinhui Li. Issues Related to Oxygen Used in the Resuscitation of Preterm Infants in Delivery Room[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2014, 10(06): 807-810.

在我国,新生儿尤其是早产儿窒息发生率较高。近年高氧血症对新生儿的危害越来越受到重视,产房复苏中如何合理用氧的观点亦发生了巨大改变。目前多数研究资料及相关指南仅局限于足月儿产房复苏中如何合理用氧,将足月儿研究的结论应用于早产儿并不适合。早产儿产房复苏技术的进一步完善,对提高窒息早产儿存活率和减少神经系统后遗症有极大帮助。将早产儿窒息复苏用氧治疗中新的研究成果进行及时推广和应用,具有重要的临床价值和社会意义。

There is high incidence of neonatal asphyxia in China, especially among preterm infants. The harm of hyperoxia on neonates has been more and more focused in recent years, accompaning with great changes on how to use oxygen reasonably in delivery room. Most research data and related guidelines were limited to full-term infants, which were not suitable for preterm infants. More and more preterm infants will survive without serious neurological sequelae with further improvement on resuscitation of in the delivery room. Appropriate promotion and application of new perspectives in resuscitation of preterm infants has important clinical values and social significance.

[1]
Lawn JE, Blencowe H, Oza S, et al. Every Newborn: progress, priorities, and potential beyond survival [J]. Lancet, 2014, 384(9938):189–205.
[2]
Moore T, Hennessy EM, Myles J, et al. Neurological and developmental outcome in extremely preterm children born in England in 1995 and 2006: the EPICure studies[J]. BMJ, 2012, 345 :e7961.
[3]
Chessex P, Watson C, Kaczala GW, et al. Determinants of oxidant stress in extremely low birth weight premature infants[J]. Free Radic Biol Med, 2010, 49(9) : 1380–1386.
[4]
Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production [J]. Pediatr Res, 1988, 23(2):143–150.
[5]
Georgeson GD, Szony BJ, Streitman K, et al. Antioxidant enzyme activities aredecreased in preterm infants and in neonates born via caesarean section[J]. Eur JObstet Gynecol Reprod Biol, 2002, 103(2) : 136–139.
[6]
Mocatta TJ, Winterbourn CC, Inder TE, et al. The effect of gestational age and labour on markers of lipid and protein oxidation in cord plasma[J]. Free Radic Res, 2004, 38(2) : 185–191.
[7]
Davis JM, Auten RL. Maturation of the antioxidant system and the effects on preterm birth[J]. Semin Fetal Neonatal Med, 2010, 15 (4):191–195.
[8]
Nassi N, Ponziani V, Becatti M, et al. Anti-oxidant enzymes and related elements in term and preterm newborns[J]. Pediatr Int, 2009, 51(2):183–187.
[9]
Asikainen TM, Heikkila P, Kaarteenaho-Wiik R, et al. Cellspecific expression of manganese superoxide dismutase protein in the lungs of patients with respiratory distress syndrome, chronic lung disease, or persistent pulmonary hypertension [J]. Pediatr Pulmonol, 2001, 32(3): 193–200.
[10]
Gien J, Kinsella JP. Pathogenesis and treatment of bronchopulmonary dysplasia[J]. Curr Opin Pediat, 2011, 23(3): 305–313.
[11]
Manzano RM, Mascaretti RS, Carrer V, et al. A hyperoxic lung injury model in premature rabbits : the influence of different gestational ages and oxygen concentrations[J]. PLoS One, 2014, 9(4):e95844.
[12]
Richter J, Toelen J, Vanoirbeek J, et al. Functional assessment of hyperoxia-induced lung injury after preterm birth in the rabbit [J]. Am J Physiol Lung Cell Mol Physiol, 2014, 306(3): L277–L283.
[13]
Buczynski BW, Maduekwe, ET, O'Reilly MA. The role of hyperoxia in the pathogenesis of experimental BPD [J]. Semin Perinatol, 2013, 37(2): 69–78.
[14]
Sirinyan M, Sennlaub F, Dorfman A, et al. Hyperoxic exposure leads to nitrative stress and ensuing microvascular degeneration and diminished brain mass and function in the immature subject [J]. Stroke, 2006, 37(11):2807–2815.
[15]
Ritter J, Schmitz T, Chew LJ, et al. Neonatal hyperoxia exposure disrupts axon-oligodendrocyte integrity in the subcortical white matter[J]. J Neurosci, 2013, 33(21) : 8990–9002.
[16]
Schmitz T, Ritter J, Mueller S, et al. Cellular changes underlying hyperoxia-induced delay of white matter development [J]. J Neurosci, 2011, 31(11): 4327–4344.
[17]
Rabi Y, Singhal N, Nettel-Aguirre A. Room-air versus oxygen administration for resuscitation of preterm infants: the ROAR study[J]. Pediatrics, 2011, 128(2) : e374–e381.
[18]
Wang CL, Anderson C, Leone TA, et al. Resuscitation of preterm neonates by using room air or 100% oxygen [J]. Pediatrics, 2008, 121(6) : 1083–1089.
[19]
Saugstad OD. Resuscitation of newborn infants: from oxygen to room air[J]. Lancet, 2010, 376(9757) : 1970–1971.
[20]
Kapadia VS, Chalak LF, Sparks JE, et al. Resuscitation of preterm neonates with limited versus high oxygen strategy [J]. Pediatrics, 2013, 132(6) :e1488–e1496.
[21]
Rook D, Schierbeek H, van der Eijk AC, et al. Resuscitation of very preterm infants with 30% vs 65 % oxygen at birth: study protocol for a randomized controlled trial[J]. Trials, 2012, 13:65.
[22]
Perlman JM, Wyllie J, Kattwinkel J, et al. Part 11, neonatal resuscitation: 2010 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations[J]. Circulation, 2010, 122 (Suppl 2) : S516–S538.
[23]
Hunyadi-Anticevic S, Colak Z, Funtak IL, et al. European Resuscitation Council guidelines for resuscitation 2010 [J]. Lijec Vjesn, 2011, 133(1-2): 1–14.
[24]
中国新生儿复苏项目专家组.新生儿复苏指南(2011年北京修订)[J].中国当代儿科杂志,2011,13 (9):691–695.
[25]
Sweet DG, Carnielli V,Greisen G,et al. European Consensus Guidelines on the Management of Neonatal Respiratory Distress Syndrome in Preterm Infants––2013 update [J]. Neonatology, 2013, 103(4):353–368.
[26]
Committee on Fetus and Newborn, American Academy of Pediatrics. Respiratory support in preterm infants at birth [J]. Pediatrics, 2014, 133(1): 171–174.
[27]
Dawson JA, Vento M, Finer NN, et al. Managing oxygen therapy during delivery room stabilization of preterm infants[J]. J Pediatr, 2012, 160(1) : 158–161.
[28]
Saugstad OD, Aune D. Optimal oxygenation of extremely low birth weight infants: a Meta-analysis and systematic review of the oxygen saturation target studies[J]. Neonatology, 2014, 105(1) : 55–63.
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