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中华妇幼临床医学杂志(电子版) ›› 2014, Vol. 10 ›› Issue (01) : 48 -52. doi: 10.3877/cma.j.issn.1673-5250.2014.01.011

所属专题: 文献

论著

早期宫颈浸润癌术后静脉血栓形成的危险因素分析
罗成燕1, 范文1, 姜旖1, 傅士龙1, 程文俊1,*,*()   
  1. 1. 210029 江苏,南京医科大学第一附属医院妇科
  • 收稿日期:2013-12-12 修回日期:2014-01-06 出版日期:2014-02-01
  • 通信作者: 程文俊

Risk Factors Analysis of Postoperative Venous Thromboembolism in Early Stage Cervical Carcinoma

Chengyan Luo1, Wen Fan1, Yi Jiang1, Shilong Fu1, Wenjun Cheng1()   

  1. 1. Department of Gynecology, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
  • Received:2013-12-12 Revised:2014-01-06 Published:2014-02-01
  • Corresponding author: Wenjun Cheng
  • About author:
    (Corresponding author: Cheng Wenjun, Email: )
引用本文:

罗成燕, 范文, 姜旖, 傅士龙, 程文俊. 早期宫颈浸润癌术后静脉血栓形成的危险因素分析[J/OL]. 中华妇幼临床医学杂志(电子版), 2014, 10(01): 48-52.

Chengyan Luo, Wen Fan, Yi Jiang, Shilong Fu, Wenjun Cheng. Risk Factors Analysis of Postoperative Venous Thromboembolism in Early Stage Cervical Carcinoma[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2014, 10(01): 48-52.

目的

探讨早期宫颈浸润癌术后静脉血栓(VTE)形成的危险因素及其预防措施。

方法

选择2010年1月至2013年6月在南京医科大学第一附属医院妇科接受手术治疗且临床和随访资料完整的243例早期宫颈浸润癌患者为研究对象(本研究遵循的程序符合南京医科大学第一附属医院人体试验委员会所制定的伦理学标准,得到该委员会批准,并征得受试对象本人的知情同意,与之签署临床研究知情同意书),对其术后VTE形成的相关因素进行单因素和多因素非条件logistic回归分析。

结果

术后VTE形成发生率为7.8% (19/ 243 ).多因素非条件logistic回归分析结果显示体质量指数(BMI)[OR =1.23,95 %CI(1.08~ 1.47),P=0.030]、吸烟[OR=2.42, 95%CI(2.11~ 5.31),P=0.010]、既往合并其他恶性肿瘤[OR=6.49, 95%CI(1.23~ 26.16),P=0.001]、既往血栓病史[OR=4.62, 95%CI(1.01~ 6.95),P=0.000]、术后第3天D-二聚体水平升高[OR=2.99,95%CI(1.27~ 4.22),P=0.023]是早期子宫颈浸润癌术后VTE形成的独立危险因素。

结论

早期宫颈浸润癌患者需在术前对VTE形成相关危险因素进行准确评估,采用及时有效的预防措施,有效降低术后VTE形成的发生率。

Objective

To explore the high risk factors of postoperative venous thromboembolism (VTE) among patients undergoing surgery for stageⅠA2-ⅡA cervical carcinoma, for distinguishing the high-risk patients and establishing preventive strategy.

Methods

From January 2010 to July 2013, a retrospective study was carried out in the 243 patients with stageⅠA2-ⅡA cervical carcinoma who underwent surgery. The high risk factors for postoperative VTE were investigated. Various clinic-pathologic variables were tested for an association with the development of postoperative VTE using standard statistical tests. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of The First Affiliated Hospital with Nanjing Medical University. Informed consent was obtained from each patients.

Results

The incidence rate of VTE was 7.8% (19/ 243) in the study.Multivariate logistic regression analysis indicated that elevated body mass index (BMI) [OR=1.23, 95% CI (1.08-1.47) , P=0.030], cigarette smoking[OR=2.42, 95 %CI(2.11-5.31) , P=0.010], a history of VTE [OR=6.49, 95%CI(1.23-26.16) , P=0.001]and cancer[OR=4.62, 95%CI(1.01-6.95) , P=0.000], and elevated levels of D-dimer on the 3rd day post-surgery [OR=2.99, 95%CI(1.27-4.22) , P=0.023] were independent risk factors for postoperative VTE.

Conclusions

Each patient with early stage cervical cancer before surgery should be assessed for postoperative thromboembolic risk according to the risk factors identified in this study. Prophylaxis therefore should be used to prevent postoperative VTE events.

表1 术后VTE形成相关因素的单因素分析结果[n(%)]
Table 1 Univariate analysis for factors association with postoperative VTE[n(%)]
表2 术后VTE形成危险因素的多因素非条件logistic回归分析结果
Table 2 Multivariate unconditional logistic regression analysis for factors association with postoperative VT E
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