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中华妇幼临床医学杂志(电子版) ›› 2013, Vol. 09 ›› Issue (06) : 787 -789. doi: 10.3877/cma.j.issn.1673-5250.2013.06.016

所属专题: 文献

论著

早产儿视网膜病变的筛查分析
刘阳1,*,*(), 杜逸亭1   
  1. 1. 610031 成都市妇女儿童中心医院新生儿科实业街分部
  • 收稿日期:2013-06-10 修回日期:2013-10-10 出版日期:2013-12-01
  • 通信作者: 刘阳

Screening Analysis of Retinopathy of Prematurity in Premature Infants

Yang LIU1(), Yi-ting DU1   

  1. 1. Neonatology Department, Division of Shi ye Street, Chengdu Women'sand Children's Center Hospital, Chengdu 610031, Sichuan Province, China
  • Received:2013-06-10 Revised:2013-10-10 Published:2013-12-01
  • Corresponding author: Yang LIU
  • About author:
    (Corresponding author : LIU Yang, Email: )
引用本文:

刘阳, 杜逸亭. 早产儿视网膜病变的筛查分析[J]. 中华妇幼临床医学杂志(电子版), 2013, 09(06): 787-789.

Yang LIU, Yi-ting DU. Screening Analysis of Retinopathy of Prematurity in Premature Infants[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2013, 09(06): 787-789.

目的

探讨早产儿视网膜病变(ROP)的临床特点。

方法

选择2010年7月8日至2012年9月6日在成都市妇女儿童中心医院新生儿科实业街分部收治的93例接受ROP筛查的早产儿、低出生体重(LBW)儿为研究对象。其中,男性为48例,女性为45例,平均出生体重为(1547 ± 345)g,胎龄为(27~ 36)孕周,平均为(31±2)孕周(本研究遵循的程序符合本院人体试验委员会制定的伦理学标准,得到该委员会批准,并征得患儿家属的知情同意)。回顾性分析其ROP的临床特点。

结果

93例接受ROP筛查的儿童中,10例出现ROP,发病率为10.75%。体重<1200 g者ROP发病率为3. 23 % (3/93) ,(1200~1700)g为5. 38%(5/93),(1701~2200)g为2. 15% (2/93)。分娩孕龄 ≤30孕周的ROP发病率为4. 30% (4/93),分娩孕周为(31~32)孕周的ROP发病率为6.45 % (6/93)。ROP相关因素的疾病表现为呼吸暂停(χ2 = 5. 03,P<0. 05)、新生儿呼吸窘迫综合征(NRDS)(χ2 =6. 84,P<0. 05)、新生儿肺炎(χ2 = 7. 55,P<0. 05)、病理性黄疸(χ2 = 3. 98,P<0. 05)、窒息(χ2 = 8. 46 ,P<0. 05)和呼吸机相关性肺炎(VAP) (χ2 =3. 56,P< 0.05)。

结论

早产儿应及时行规范的眼底检查,对ROP应早发现、早治疗。

Objective

To investigate the clinical features of retinopathy of prematurity (ROP).

Methods

From July 2010 to September 2012, a total of 93 cases (48 boys and 45 girls) of premature and low birth weight (LBW) infants were included into this study. They were received ROP screening in Neonatology Department of Chengdu Women's and Children's Center Hospital. Their average birth weight was (1547±345) g, gestational age varied from 27 to 36 gestational weeks, and the average gestational age was (31 ± 2) weeks. The procedure followed in this study met the hospital ethical standards established by the Institutional Review Board, obtained its approval and the informed consent from the families of children. The retrospective analysis of the clinical features of ROP were conducted.

Results

In these 93 cases, ten were found of ROP and the incidence rate was 10. 75%. The incidence rate of ROP of weight less than 1200 g was 3. 23% (3/93), (1200-1700)g was 5. 38% (5/93) , (1701-2200) g was 2. 15% (2/93). The related factors of ROP were apnea (χ2 =5. 03, P<0. 05),neonatal respiratory distress syndrome (NRDS) (χ2 =6. 84, P< 0. 05) , pneumonia of newborn (χ2 = 7. 55, P<0. 05) , jaundice (χ2= 3. 98,P< 0. 05), asphyxia (χ2 = 8. 46 , P < 0. 05) , and ventilator associated pneumonia (VAP) (χ2 = 3. 56, P < 0. 05).

Conclusions

Premature infants should take normal fundus examination to detect ROP as early as possible.

表1 早产儿的相关因素分析[n(%)]
Table 1 Related factors analysis of ROP of preterm infants[n(%)]
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Experts Group for the Guidelines of Prevention and Treatment of Retinopathy in Premature Infants. Guidelines for therapeutic use of oxygen and prevention and treatment of retinopathy in premature infants[J]. Chin J Pediatr, 2007,45 (9) : 672-673.
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International Committee for the Classification of Retinopathy of Prematurity. The International Classification of Retinopathy of Prematurity Revisited [J]. Arch Optthalmol, 2005,123(7) : 991-999.
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Wheatley CM, Dickinson JL, Mackey DA, et al. Retinopathy of prematurity: Recent advances in our understanding [J]. Arch Dis Child Fetal Neonatal Ed, 2002,87(2):78.
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