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中华妇幼临床医学杂志(电子版) ›› 2013, Vol. 09 ›› Issue (05) : 692 -695. doi: 10.3877/cma.j.issn.1673-5250.2013.05.031

所属专题: 文献

综述

肺炎支原体的耐药机制及治疗
张涛1,*,*(), 王穗琼1   
  1. 1. 510010 广东,广州医科大学附属广东省妇女儿童医院儿科
  • 收稿日期:2013-06-10 修回日期:2013-09-29 出版日期:2013-10-01
  • 通信作者: 张涛

Summarized on Drug Resistance Mechanism and Treatment in Mycoplasma Pneumoniae Infection

Tao ZHANG1(), Sui-qiong WANG1   

  1. 1. Department of Peadiatrics, Guangdong Women and Children Hospital, Guangzhou 510010, Guangdong Province, China
  • Received:2013-06-10 Revised:2013-09-29 Published:2013-10-01
  • Corresponding author: Tao ZHANG
  • About author:
    (Corresponding author: ZHANG Tao, Email: )
引用本文:

张涛, 王穗琼. 肺炎支原体的耐药机制及治疗[J/OL]. 中华妇幼临床医学杂志(电子版), 2013, 09(05): 692-695.

Tao ZHANG, Sui-qiong WANG. Summarized on Drug Resistance Mechanism and Treatment in Mycoplasma Pneumoniae Infection[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2013, 09(05): 692-695.

肺炎支原体(MP)为常见的儿童呼吸道感染病原体之一。随着大环内酯类抗菌药物的广泛应用,耐大环内酯抗菌药物菌(MRMP)呈上升趋势,MRMP感染人群已向成年人蔓延。MRMP较敏感菌株导致感染个体的临床症状持续时间长,肺外并发症发病率高。笔者拟就肺炎支原体流行病学、耐药机制及MRMP的治疗,综述如下。

Mycoplasma pneumoniae is one of major pathogens in community acquired respiratory tract in children and adults. But with macrolides abused, the macrolide-resistance Mycoplasma pneumoniae (MRMP) were dramatically grown, and the MRMP infection spreaded from children to adults in recent years. Many studies demonstrated that the clinical symptoms of MRMP infection were longer and extrapulmonary complications incidence rate was higher than the sensitive strain infection. In this paper, epidemiology、mechanism of resistance and drug resistant strain's treatment of Mycoplasma pneumoniae were summarized by review literatures.

1
Atkinson TP, Balish MF, Waites KB. Epidemiology, clinical manifestations, pathogenesis and laboratory detection of Mycoplasma pneumoniae infections[J]. FEMS Microbiol Rev, 2008,32(6):956-973.
2
Lee KY. Pediatric respiratory infections by Mycoplasma pneumoniae[J]. Expert Rev Anti Infect Ther, 2008,6(4):509-521.
3
Spuesens E B, Fraaij P L, Visser E G, et al. Carriage of Mycoplasma pneumoniae in the upper respiratory tract of symptomatic and asymptomatic children: An observational study[J]. PLoS Med, 2013,10(5):e1001444.
4
Miyashita N, Kawai Y, Akaike H, et al. Macrolide-resistant Mycoplasma pneumoniae in adolescents with community-acquired pneumonia[J]. BMC Infect Dis, 2012,12:126.
5
Xin D, Mi Z, Han X, et al. Molecular mechanisms of macrolide resistance in clinical isolates of Mycoplasma pneumoniae from China[J]. Antimicrob Agents Chemother, 2009,53(5):2158-2159.
6
Dumke R, von Baum H, Luck PC, et al. Occurrence of macrolide-resistant Mycoplasma pneumoniae strains in Germany[J]. Clin Microbiol Infect, 2010,16(6):613-616.
7
Peuchant O, Menard A, Renaudin H, et al. Increased macrolide resistance of Mycoplasma pneumoniae in France directly detected in clinical specimens by real-time PCR and melting curve analysis[J]. J Antimicrob Chemother, 2009,64(1):52-58.
8
Oishi T, Narita M, Ohya H, et al. Rhabdomyolysis associated with antimicrobial drug-resistant Mycoplasma pneumoniae[J]. Emerg Infect Dis, 2012,18(5):849-851.
9
Park IH, Choi DY, Oh YK, et al. A case of acute myopericarditis associated with Mycoplasma pneumoniae infection in a child[J]. Korean Circ J, 2012,42(10):709-713.
10
Shimizu M, Hamaguchi Y, Matsushita T, et al. Sequentially appearing erythema nodosum, erythema multiforme and Henoch-Schonlein purpura in a patient with Mycoplasma pneumoniae infection: A case report[J]. J Med Case Rep, 2012,6(1):398.
11
Berg CP, Kannan TR, Klein R, et al. Mycoplasma antigens as a possible trigger for the induction of antimitochondrial antibodies in primary biliary cirrhosis[J]. Liver Int, 2009,29(6):797-809.
12
Cao B, Zhao CJ, Yin YD, et al. High prevalence of macrolide resistance in Mycoplasma pneumoniae isolates from adult and adolescent patients with respiratory tract infection in China[J]. Clin Infect Dis, 2010,51(2):189-194.
13
Matsubara K, Morozumi M, Okada T, et al. A comparative clinical study of macrolide-sensitive and macrolide-resistant Mycoplasma pneumoniae infections in pediatric patients[J]. J Infect Chemother, 2009,15(6):380-383.
14
Wang Y, Qiu S, Yang G, et al. An outbreak of Mycoplasma pneumoniae caused by a macrolide-resistant isolate in a nursery school in China[J]. Antimicrob Agents Chemother, 2012,56(7):3748-3752.
15
Kannan T R, Hardy R D, Coalson J J, et al. Fatal outcomes in family transmission of Mycoplasma pneumoniae[J]. Clin Infect Dis, 2012,54(2):225-231.
16
Morozumi M, Takahashi T, Ubukata K. Macrolide-resistant Mycoplasma pneumoniae: Characteristics of isolates and clinical aspects of community-acquired pneumonia[J]. J Infect Chemother, 2010,16(2):78-86.
17
Morozumi M, Iwata S, Hasegawa K, et al. Increased macrolide resistance of Mycoplasma pneumoniae in pediatric patients with community-acquired pneumonia[J]. Antimicrob Agents Chemother, 2008,52(1):348-350.
18
Liu Y, Ye X, Zhang H, et al. Antimicrobial susceptibility of Mycoplasma pneumoniae isolates and molecular analysis of macrolide-resistant strains from Shanghai, China[J]. Antimicrob Agents Chemother, 2009,53(5):2160-2162.
19
Zhao F, Lv M, Tao X, et al. Antibiotic sensitivity of 40 Mycoplasma pneumoniae isolates and molecular analysis of macrolide-resistant isolates from Beijing, China[J]. Antimicrob Agents Chemother, 2012,56(2):1108-1109.
20
Isozumi R, Yoshimine H, Morozumi M, et al. Adult community-acquired pneumonia caused by macrolide resistant Mycoplasma pneumoniae[J]. Respirology, 2009,14(8):1206-1208.
21
Waites KB, Balish MF, Atkinson TP. New insights into the pathogenesis and detection of Mycoplasma pneumoniae infections[J]. Future Microbiol, 2008,3(6):635-648.
22
Wolff BJ, Thacker WL, Schwartz SB, et al. Detection of macrolide resistance in Mycoplasma pneumoniae by real-time PCR and high-resolution melt analysis[J]. Antimicrob Agents Chemother, 2008,52(10):3542-3549.
23
Liu XJ, Xin DL, Li J,et al.Molecular mechanisms of macrolides resistance in Mycoplasma pneumoniae[J].J Appl Clin Pediatr, 2008,23(22):1730-1733.
24
Pereyre S, Guyot C, Renaudin H, et al. In vitro selection and characterization of resistance to macrolides and related antibiotics in Mycoplasma pneumoniae[J]. Antimicrob Agents Chemother, 2004,48(2):460-465.
25
Ye Y, Li SL, Jiang P,et al.Analysis on Mycoplasma pneumoniae 23SrRNA gene mutation site and drug resistance phenotype[J].Lab Med, 2013,28(1):11-16.
26
Morozumi M, Hasegawa K, Kobayashi R, et al. Emergence of macrolide-resistant Mycoplasma pneumoniae with a 23S rRNA gene mutation[J]. Antimicrob Agents Chemother, 2005,49(6):2302-2306.
27
Pan MA, Zhang TT, Zhu JX, et al.The study of drug resistance and mechanism of azithromycin for Mycoplasma pneumoniae[J].Chin J Antibio,2010(09):721-725.
28
Shi DW.Study on the induction of resistance to azithromycin in Mycoplasma pneumoniae[D].BeiJing:Capital Medical Univerity, 2010:1-49.
29
Tagliabue C, Salvatore CM, Techasaensiri C, et al. The impact of steroids given with macrolide therapy on experimental Mycoplasma pneumoniae respiratory infection[J]. J Infect Dis, 2008,198(8):1180-1188.
30
Lee KY, Lee HS, Hong JH, et al. Role of prednisolone treatment in severe Mycoplasma pneumoniae pneumonia in children[J]. Pediatr Pulmonol, 2006,41(3):263-268.
31
Tagliabue C, Techasaensiri C, Torres JP, et al. Efficacy of increasing dosages of clarithromycin for treatment of experimental Mycoplasma pneumoniae pneumonia[J]. J Antimicrob Chemother, 2011,66(10):2323-2329.
32
Averbuch D, Hidalgo-Grass C, Moses AE, et al. Macrolide resistance in Mycoplasma pneumoniae, Israel, 2010[J]. Emerg Infect Dis, 2011,17(6):1079-1082.
33
Meng Y, Huo J, Lu W, et al. Modulation of p1 and EGF expression by baicalin[J]. Int J Mol Sci, 2012,14(1):146-157.
34
Ledford JG, Mukherjee S, Kislan MM, et al. Surfactant protein-A suppresses eosinophil-mediated killing of Mycoplasma pneumoniae in allergic lungs[J]. PLoS One, 2012,7(2):e32436.
35
Gally F, Di YP, Smith SK, et al. SPLUNC1 promotes lung innate defense against Mycoplasma pneumoniae infection in mice[J]. Am J Pathol, 2011,178(5):2159-2167.
36
Szczepanek SM, Majumder S, Sheppard ES, et al. Vaccination of BALB/c mice with an avirulent Mycoplasma pneumoniae P30 mutant results in disease exacerbation upon challenge with a virulent strain[J]. Infect Immun, 2012,80(3):1007-1014.
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