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中华妇幼临床医学杂志(电子版) ›› 2013, Vol. 09 ›› Issue (04) : 485 -487. doi: 10.3877/cma.j.issn.1673-5250.2013.04.013

所属专题: 文献

论著

先天性梅毒新生儿血小板参数变化及其临床意义
舒桂华1,*,*(), 徐翔1, 严语1, 蔡闫闫1, 侯玮玮1, 朱玲玲1   
  1. 1. 225001 江苏扬州,江苏扬州大学临床医学院新生儿科
  • 收稿日期:2013-05-12 修回日期:2013-07-11 出版日期:2013-08-01
  • 通信作者: 舒桂华

Change of Platelet Parameters and Its Clinical Significance in Neonates With Congenital Syphilis

Gui-hua SHU1(), Xiang XU1, Yu YAN1, Yan-yan CAI1, Wei-wei HOU1, Ling-ling ZHU1   

  1. 1. Department of Neonatology, Clinic Medical College, Yangzhou University, Yangzhou 225001, Jiangsu Province, China
  • Received:2013-05-12 Revised:2013-07-11 Published:2013-08-01
  • Corresponding author: Gui-hua SHU
  • About author:
    (Corresponding author: SHU Gui-hua, Email: )
引用本文:

舒桂华, 徐翔, 严语, 蔡闫闫, 侯玮玮, 朱玲玲. 先天性梅毒新生儿血小板参数变化及其临床意义[J]. 中华妇幼临床医学杂志(电子版), 2013, 09(04): 485-487.

Gui-hua SHU, Xiang XU, Yu YAN, Yan-yan CAI, Wei-wei HOU, Ling-ling ZHU. Change of Platelet Parameters and Its Clinical Significance in Neonates With Congenital Syphilis[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2013, 09(04): 485-487.

目的

探讨先天性梅毒(CS)新生儿血小板(PLT)参数的变化及其临床意义。

方法

选择2005年2月至2013年2月扬州大学临床医学院新生儿科收治的78例CS患儿为研究对象。根据临床症状将其分为症状性CS组(n=38)和无症状性CS组(n=40),根据其母体妊娠期接受青霉素治疗情况将其分为母体治疗组(n=54)和母体未治疗组(n=24),随机选取同期于本院产科出生的39例正常新生儿纳入对照组(n=39)(本研究遵循的程序符合本院人体试验委员会所制定的伦理学标准,得到该委员会批准,并征得受试对象监护人的知情同意,与之签署临床研究知情同意书)。各组新生儿胎龄、出生体重、性别等一般情况比较,差异无统计学意义(P>0.05)。测定各组新生儿PLT计数、平均血小板体积(MPV)及血小板分布宽度(PDW)。

结果

症状性CS组和无症状性CS组新生儿早期PLT计数较对照组显著降低,而MPV,PDW较对照组显著增高,前两者分别与后者比较,差异有统计学意义(P<0.05)。症状性CS组和无症状性CS组新生儿治疗第1 d和第13 d PLT计数,MPV和PDW水平比较,差异有统计学意义(P<0.05),而上述两组第13 d PLT计数,MPV和PDW水平与对照组比较,差异无统计学意义(P>0.05)。母体未治疗组CS新生儿PLT计数水平较母体治疗组和对照组均显著降低,MPV,PDW显著增高,前者与后两者相比,差异有统计学意义(P<0.05)。

结论

PLT参数的变化对新生儿CS病情程度及疗效判断具有一定参考价值。

Objective

To explore the change of platelet (PLT) parameters and its clinical significance in neonates with congenital syphilis (CS).

Methods

From February 2005 to 2013, a totle of 78 neonates with CS were included in the study, and divided into symptom group(n=38) and non-symptom group(n=40) according to their clinical symptoms.They were divided into mother treated group(n=54) and mother non-treated group (n=24) as well according to their mothers' treatment during pregnancy.Meanwhile 39 normal neonates were chosen as control group(n=29). PLT count, mean platelet volume(MPV) and platelet distribution width ( PDW) were detected in the first day and the 13th day after being treated.The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Clinic Medical College of Yangzhou University.Informed consent was obtained from each parents.There were no significant differenc in general clinical data among these groups(P>0.05).

Results

PLT count in symptom group during the early stage were obviously lower than those of non-symptom group and control group( P<0.05), meanwhile MPV and PDW were obviously higher than those of other two groups(P<0.05). There had significant differences in PLT count, MPV and PDW at the first day and the 13th day after being treated between symptom group and non-symptom group(P<0.05). There was no significantly difference of PLT wount, MPV and PDW at the 13th day after being treated among symptom group, non-symptom group and control group(P>0.05). PLT count in mother non-treated group was lower than that of mother treated group and control group (P<0.05), and MPV and PDW were obviously higher than those of other two groups(P<0.05).

Conclusions

Changes of PLT parameters can be of reference value for determining the severity of damage and the curative effects of neonates with CS.

表1 3组不同临床症状新生儿PLT参数比较(±s)
Table 1 Comparison of platelet parameters among three different clinical symptoms groups(±s)
表2 3组不同母体治疗情况新生儿PLT参数比较(±s)
Table 2 Comparison of platelet parameters among three different treatment groups (±s)
1
Vasquez-Manzanilla O, Dickson-Gonzalez SM, Salas JG,et al. Congenital syphilis in Valera, Venezuela[J].J Trop Pediatr,2007,53(4):274-277.
2
Chen ZQ, Zhang GC, Gong XD,et al.Syphilis in China:Results of a national surveillance programme[J].Lancet,2007,369(9556):132-138.
3
Israels SJ. Diagnostic evaluation of platelet function disorders in neonates and children: An update[J].Semin Thromb Hemost,2009,35(2):181-188.
4
Sun ZX, Peng XM, Chen M.et al. Diagnosis and treatment of congenital syphilis in 73 children. J Appl Clin Pediatr,2006,21(22):1552-1567.
5
Shao XM, Ye HM, Qiu XS, et al.Practice of neonatology.4th ed[M]. Beijing:People's Medical Publishing House,2004:355-357.
6
Gao A.Prevention and early diagnosis of neonatal congenital syphilis[J]. Chin J Neonatol, 2011,26(5):300-303.
7
Li LX, Zhao L, Li YH,et al. Dynamical changes of platelet parameter on neonatal infectious pneumonia[J]. Chin J Neonatol,2010,25(3):172-173.
8
Witzenrath M, Gutbier B, Owen JS, et al. Role of platelet activating factor in pneumolysin-induced acute lung injury[J]. Crit Care Med, 2007, 35(7):1756-1762.
9
Mavrommatis AC, Theodoridis T, Orfanidou A, et al. Coagulation system and platelets are fully activated in uncomplicated sepsis[J].Crit Care Med,2000,28(2):451-457.
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