双胎妊娠合并妊娠期肝内胆汁淤积症对母婴预后的影响

doi:10.3877/cma.j.issn.1673-5250.2013.03.019

中华妇幼临床医学杂志(电子版) ›› 2013, Vol. 09 ›› Issue (03) : 364 -367. doi: 10.3877/cma.j.issn.1673-5250.2013.03.019

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短篇论著

双胎妊娠合并妊娠期肝内胆汁淤积症对母婴预后的影响

赵军¹, 蒋洁¹, 姜孙¹, 邓丽琴¹, 项静英¹, 张岩¹^,^*(

)

^1. 214002　江苏无锡，无锡市妇幼保健院

收稿日期:2013-03-19 修回日期:2013-05-12 出版日期:2013-06-01
通信作者: 张岩
基金资助:
基金资助项目：无锡市科技局社会发展基金(CSZ00947)

Received:2013-03-19 Revised:2013-05-12 Published:2013-06-01

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表1 4组孕妇一般状况比较(±s)

Table 1 Comparison of general condition among four groups(±s)

组别	n	年龄(岁)	体重(kg)	身高(cm)	孕次(次)	孕龄(孕周)	胎心率(次/min)
双胎ICP组	83	27.19±3.71	71.46±8.65	161.16±4.54	1.88±1.34	34.90±1.86	143.20±6.87
单胎ICP组	100	27.56±4.56	67.45±7.90	161.08±4.92	1.85±1.03	37.30±1.75	142.95±7.12
正常双胎组	100	28.02±4.29	72.77±7.47	161.15±3.97	1.71±0.97	36.17±1.65	143.50±6.92
正常单胎组	100	27.23±3.61	67.67±8.43	160.46±3.74	1.54±0.98	38.88±1.26	141.51±5.51

表1 4组孕妇一般状况比较(±s)

Table 1 Comparison of general condition among four groups(±s)

组别	n	年龄(岁)	体重(kg)	身高(cm)	孕次(次)	孕龄(孕周)	胎心率(次/min)
双胎ICP组	83	27.19±3.71	71.46±8.65	161.16±4.54	1.88±1.34	34.90±1.86	143.20±6.87
单胎ICP组	100	27.56±4.56	67.45±7.90	161.08±4.92	1.85±1.03	37.30±1.75	142.95±7.12
正常双胎组	100	28.02±4.29	72.77±7.47	161.15±3.97	1.71±0.97	36.17±1.65	143.50±6.92
正常单胎组	100	27.23±3.61	67.67±8.43	160.46±3.74	1.54±0.98	38.88±1.26	141.51±5.51

表2 4组孕妇血清TCH，TG，ALT，AST，ALP水平比较(±s)

Table 2 Comparison of levels of TCH，TG，ALT，AST，ALP among four groups(±s)

组别	n	TCH(mmol/L)	TG(mmol/L)	ALT(IU/L)	AST(IU/L)	ALP(IU/L)
双胎ICP组	83	7.10±1.45	5.26±1.76	110.26±12.89	83.02±10.29	214.70±23.66
单胎ICP组	100	6.60±1.24^a	3.90±1.01^a	82.90±11.00^a	68.24±7.59^a	193.86±20.69^a
正常双胎组	100	6.44±1.03^a	4.47±1.02^ab	13.78±2.12^ab	17.07±3.20^ab	176.43±22.51^ab
正常单胎组	100	5.38±1.08^ac	2.75±0.88^ac	13.62±2.12^a	15.81±1.48^ac	152.21±26.22^ac
F		23.51	51.14	2308.28	1936.02	99.69
P		<0.01	<0.01	<0.01	<0.01	<0.01

表2 4组孕妇血清TCH，TG，ALT，AST，ALP水平比较(±s)

Table 2 Comparison of levels of TCH，TG，ALT，AST，ALP among four groups(±s)

组别	n	TCH(mmol/L)	TG(mmol/L)	ALT(IU/L)	AST(IU/L)	ALP(IU/L)
双胎ICP组	83	7.10±1.45	5.26±1.76	110.26±12.89	83.02±10.29	214.70±23.66
单胎ICP组	100	6.60±1.24^a	3.90±1.01^a	82.90±11.00^a	68.24±7.59^a	193.86±20.69^a
正常双胎组	100	6.44±1.03^a	4.47±1.02^ab	13.78±2.12^ab	17.07±3.20^ab	176.43±22.51^ab
正常单胎组	100	5.38±1.08^ac	2.75±0.88^ac	13.62±2.12^a	15.81±1.48^ac	152.21±26.22^ac
F		23.51	51.14	2308.28	1936.02	99.69
P		<0.01	<0.01	<0.01	<0.01	<0.01

表3 4组孕妇血清CG，E₃，TBA，TBIL，DBIL水平比较(±s)

Table 3 Comparison of level of CG，E3，TBA，TBIL，DBIL among four groups(±s)

组别	n	CG(μg/dL)	E3(μg/L)	TBA(μmol/L)	TBIL(μmol/L)	DBIL(μmol/L)
双胎ICP组	83	41.19±8.08	64.98±7.77	30.33±4.77	11.59±3.08	5.88±1.43
单胎ICP组	100	33.12±4.96^a	69.87±9.13^a	22.65±4.27^a	10.11±2.89^a	5.03±1.38^a
正常双胎组	100	3.67±0.72^ab	79.50±6.62^ab	4.54±1.76^ab	6.71±1.75^ab	2.43±1.24^ab
正常单胎组	100	3.22±0.83^ac	72.83±6.49^ac	3.68±1.59^ac	6.68±1.86^a	1.95±0.60^ac
F		1198.48	54.65	1096.61	77.41	186.49
P		<0.01	<0.01	<0.01	<0.01	<0.01

表3 4组孕妇血清CG，E₃，TBA，TBIL，DBIL水平比较(±s)

Table 3 Comparison of level of CG，E3，TBA，TBIL，DBIL among four groups(±s)

组别	n	CG(μg/dL)	E3(μg/L)	TBA(μmol/L)	TBIL(μmol/L)	DBIL(μmol/L)
双胎ICP组	83	41.19±8.08	64.98±7.77	30.33±4.77	11.59±3.08	5.88±1.43
单胎ICP组	100	33.12±4.96^a	69.87±9.13^a	22.65±4.27^a	10.11±2.89^a	5.03±1.38^a
正常双胎组	100	3.67±0.72^ab	79.50±6.62^ab	4.54±1.76^ab	6.71±1.75^ab	2.43±1.24^ab
正常单胎组	100	3.22±0.83^ac	72.83±6.49^ac	3.68±1.59^ac	6.68±1.86^a	1.95±0.60^ac
F		1198.48	54.65	1096.61	77.41	186.49
P		<0.01	<0.01	<0.01	<0.01	<0.01

表4 4组孕妇妊娠结果比较[n(%)]

Table 4 Comparison of pregnancy outcomes among four groups[n(%)]

组别	n	羊水污染	胎儿窘迫	胎膜早破	围生儿并发症	围生儿死亡	早产
双胎ICP组	83	37(45)	31(39)	15(18)	17(20)	7(8)	69(83)
单胎ICP组	100	23(23)^a	15(15)^a	10(10)	14(14)	1(1)^a	33(33)^a
正常双胎组	100	14(14)^a	12(12)^a	16(16)	10(10)^a	0(0)^a	40(40)^a
正常单胎组	100	8 (8)^ab	2 (2)^ab	3 (3)^ab	2 (2)^ab	0(0)^a	3 (3)^ab
χ²		148.38	44.73	12.84	16.60	21.19	125.16
P		<0.01	<0.01	<0.01	<0.01	<0.01	<0.01
组别	住院时间(d，±s)	剖宫产	孕妇产后出血	出生体重(kg，±s)	5 min Apgar评分(分，±s)	10 min Apgar评分(分，±s)
双胎ICP组	11.29±2.67	78(94)	40(48)	2.25±0.39	8.94±1.94	9.38±1.78
单胎ICP组	8.78±1.90^a	82(82)^a	15(15)^a	3.19±0.45^a	9.67±0.82^a	9.81±1.05^a
正常双胎组	7.88±1.76^a	72(72)^a	40(40)^a	2.54±0.49^a	9.73±0.61^a	9.92±0.26^a
正常单胎组	6.78±1.30^ab	35(35)^ab	2 (2)^ab	3.39±0.33^ab	9.98±0.13^ab	9.98±0.13^a
F/χ²	71.92	87.61	68.74	129.30	12.22	5.36
P	<0.01	<0.01	<0.01	<0.01	<0.01	<0.01

表4 4组孕妇妊娠结果比较[n(%)]

Table 4 Comparison of pregnancy outcomes among four groups[n(%)]

组别	n	羊水污染	胎儿窘迫	胎膜早破	围生儿并发症	围生儿死亡	早产
双胎ICP组	83	37(45)	31(39)	15(18)	17(20)	7(8)	69(83)
单胎ICP组	100	23(23)^a	15(15)^a	10(10)	14(14)	1(1)^a	33(33)^a
正常双胎组	100	14(14)^a	12(12)^a	16(16)	10(10)^a	0(0)^a	40(40)^a
正常单胎组	100	8 (8)^ab	2 (2)^ab	3 (3)^ab	2 (2)^ab	0(0)^a	3 (3)^ab
χ²		148.38	44.73	12.84	16.60	21.19	125.16
P		<0.01	<0.01	<0.01	<0.01	<0.01	<0.01
组别	住院时间(d，±s)	剖宫产	孕妇产后出血	出生体重(kg，±s)	5 min Apgar评分(分，±s)	10 min Apgar评分(分，±s)
双胎ICP组	11.29±2.67	78(94)	40(48)	2.25±0.39	8.94±1.94	9.38±1.78
单胎ICP组	8.78±1.90^a	82(82)^a	15(15)^a	3.19±0.45^a	9.67±0.82^a	9.81±1.05^a
正常双胎组	7.88±1.76^a	72(72)^a	40(40)^a	2.54±0.49^a	9.73±0.61^a	9.92±0.26^a
正常单胎组	6.78±1.30^ab	35(35)^ab	2 (2)^ab	3.39±0.33^ab	9.98±0.13^ab	9.98±0.13^a
F/χ²	71.92	87.61	68.74	129.30	12.22	5.36
P	<0.01	<0.01	<0.01	<0.01	<0.01	<0.01

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