宫腔镜子宫内膜息肉切除术联合去氧孕烯炔雌醇治疗子宫内膜息肉疗效观察

doi:10.3877/cma.j.issn.1673-5250.2012.06.021

中华妇幼临床医学杂志(电子版) ›› 2012, Vol. 08 ›› Issue (06) : 759 -761. doi: 10.3877/cma.j.issn.1673-5250.2012.06.021

所属专题：文献；

论著

宫腔镜子宫内膜息肉切除术联合去氧孕烯炔雌醇治疗子宫内膜息肉疗效观察

刘彦霞¹^,^*^,^*(

)

^1. 210011　江苏南京，第二军医大学长征医院南京分院妇产科

收稿日期:2012-03-31 修回日期:2012-11-05 出版日期:2012-12-01
通信作者: 刘彦霞

Therapeutic Effects of Transcervical Resection of Polyp Combined With Marvelon on Endometrial Polyps

Yan-xia LIU¹()

^1. Department of Obstetrics and Gynecology, Nanjing Branch Court of Changzheng Hospital Affiliated to Second Military Medical University, Nanjing 210011, Jiangsu Province, China

Received:2012-03-31 Revised:2012-11-05 Published:2012-12-01
Corresponding author: Yan-xia LIU
About author:
(Corresponding author: LIU Yanxia, Email: 1144371280@qq.com)

全文 ( ) 下载PDF ( ) 导出引用

目的

观察宫腔镜子宫内膜组内切除术(TCRP)联合去氧孕烯炔雌醇治疗子宫内膜息肉(EP)的疗效。

方法

选择2010年7月至2011年7月于本院门诊拟行TCRP的90例EP患者为研究对象，并按入院顺序随机纳入研究组(TCRP＋口服去氧孕烯炔雌醇，n＝45)和对照组(TCRP，n＝45)。比较两组患者治疗前、后月经情况及术后子宫内膜厚度、EP复发情况(本研究遵循的程序符合本院人体试验委员会所制定的伦理学标准，得到该委员会批准，分组征得受试对象本人的知情同意，并与之签署临床研究知情同意书)。两组患者年龄、临床症状比较，差异无统计学意义(P>0.05)。

结果

治疗6个月后，两组患者月经周期恢复正常情况比较，差异有统计学意义(χ²＝4.86，P<0.05)。研究组患者月经量减少较对照组更为显著，两组比较，差异有统计学意义(t＝3.12，P<0.05)。治疗后两患者子宫内膜平均厚度、EP复发率比较，差异也均有统计学意义(P<0.01)。

结论

TCRP联合去氧孕烯炔雌醇治疗EP能够有效缓解患者月经周期紊乱及月经量多症状，减少子宫内膜厚度，降低EP复发率。

关键词: 子宫内膜息肉, 宫腔镜, 去氧孕烯炔雌醇, 疗效

Objective

To evaluate the therapeutic effect of transcervical resection of polyp (TCRP) combined with marvelon on endometrial polyps (EP).

Methods

From July 2007 to July 2010, 90 women with EP were included in the study, and randomly divided into research group(n=45) and control group(n=45). Research group accepted TCRP combined with marvelon for treatment, meanwhile control group accepted TCRP for treatment only. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Nanjing Branch Court of Changzheng Hospital Affiliated to Second Military Medical University.Informed consent was obtained from each patient.The menstrual circle recovery, menstrual blood volume before and after treatment, endometrial thickness and polyp relapse rate were compared between two groups.

Results

90 patients were successfully complete surgery. There had significant difference in menstrual circle recovery between two groups (χ²=4.86, P<0.05). Research group showed obvious decrease of the menstrual blood volume than that of control group(t=3.12, P<0.05). The endometrial thickness of research group was obviously smaller than that of control group(t=2.55, P<0.05), and the polyp relapse rate was less than that of control group (4.44% vs. 24.44%)(χ²=11.39, P<0.01).

Conclusions

TCRP combined with marvelon is effective in the treatment of EP, it can effectively improve menstrual disorder, and decrease polyp relapse rate.

Key words: endometrial polyps, hysteroscope, marvelon, effect

表1 两组患者月经改变情况比较[n(%)]

Table 1 Comparison of menstrual changes between two groups[n(%)]

组别	n	治疗后月经周期		月经量(±s，mL)
组别	n	正常	不正常^a	治疗前	治疗后
研究组	45	41(91.1)	4(8.9)	357.2±89.6	146.7±51.0
对照组	45	33(73.3)	12(26.7)	361.4±88.5	263.2±66.8
χ²/t	?	4.86	4.86	0.70	3.12
P	?	<0.05	<0.05	>0.05	<0.05

表1 两组患者月经改变情况比较[n(%)]

Table 1 Comparison of menstrual changes between two groups[n(%)]

组别	n	治疗后月经周期		月经量(±s，mL)
组别	n	正常	不正常^a	治疗前	治疗后
研究组	45	41(91.1)	4(8.9)	357.2±89.6	146.7±51.0
对照组	45	33(73.3)	12(26.7)	361.4±88.5	263.2±66.8
χ²/t	?	4.86	4.86	0.70	3.12
P	?	<0.05	<0.05	>0.05	<0.05

表2 两组术后子宫内膜厚度及EP复发情况比较(±s)

Table 2 Comparison of endometrial thickness and poly relapse rate between two groups after treatment(±s)

分组	n	子宫内膜平均厚度(mm)	EP复发率[n(%)]
研究组	45	7.83±1.25	2 (4.44)
对照组	45	9.80±1.13	11(24.44)
t/χ²	?	2.55	11.39
P	?	<0.05	<0.01

表2 两组术后子宫内膜厚度及EP复发情况比较(±s)

Table 2 Comparison of endometrial thickness and poly relapse rate between two groups after treatment(±s)

分组	n	子宫内膜平均厚度(mm)	EP复发率[n(%)]
研究组	45	7.83±1.25	2 (4.44)
对照组	45	9.80±1.13	11(24.44)
t/χ²	?	2.55	11.39
P	?	<0.05	<0.01

[1]	Xia EL.Gynecologic endoscopy[M]. Beijing:People's Medical Publishing House, 2001:558-560.
[2]	Feng LM, Wang WJ, Zhang HX, et al. Clinical study of hysteroscopic surgery for endometrial polyps[J]. Chin J Obstet Gynecol, 2003, 38(10):357-358.
[3]	Xu T, Lu HJ. Comparison between clinical pathological analysis of endometrial polyps and diagnosis of hysteroscopy[J]. Matern Child Health Care China, 2005, 20(9):66-67.
[4]	Feng LM, Xia EL, Cong J, et al. Assessment of blood loss with menstruation blood loss map[J]. Chin J Obstet Gynecol, 2001, 36(1):51.
[5]	Jiao X, Zhao H, Chen ZJ. Etiology progress of endometrial polyps[J]. Chin J Obstet Gynecol, 2011, 46(6):128-130.
[6]	Luo XM, Cheng QR, Meng XJ, et al. Factors associated with pathogenesis of endometrial polyps[J]. Chin Gen Pract, 2010, 13(6):18-20.
[7]	Wang X, Huang XH. Progress on surgical treatment and prevention of recurrence in endometrial polyps[J]. Chin J Obstet Gynecol, 2011, 46(4):65-67.
[8]	Tang HR, Wang LP, Chen XL, et al. The surgery treatment of endometrial polyps and the prevention of polyps recurrence[J]. Chin J Clin Obstet Gynecol, 2010, 11(3):190-191.
[9]	Hu BH, Huang H. Application of marvelon after resection of endometrial polyps[J]. J Nanchang Univ:Med Sci, 2011, 51(2):49-51.
[10]	Gao H, Long Y, Gao J, et al. Value of marvelon in the treatment of endometrial polyps[J]. J Qiqihar Univ Med, 2011, 32(5):45-46.

[1]	张舒沁, 陈练. 产后宫腔内妊娠物残留的诊断和临床处理[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 493-497.
[2]	王杰, 袁泉, 王玥琦, 乔佳君, 谭春丽, 夏仲元, 刘守尧. 溃疡油在糖尿病足溃疡治疗中的应用效果及安全性观察[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(06): 480-484.
[3]	聂生军, 王钰, 王毅, 鲜小庆, 马生成. 复方倍他米松局部注射联合光动力疗法治疗小型瘢痕疙瘩的临床疗效观察[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(05): 404-410.
[4]	莫淇舟, 苏劲, 黄健, 李健维, 李思宁, 柳建军. 智能控压输尿管软镜碎石吸引取石术在直径10～25 mm上尿路结石中的应用[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(05): 497-502.
[5]	李义亮, 苏拉依曼·牙库甫, 麦麦提艾力·麦麦提明, 克力木·阿不都热依木. 机器人与腹腔镜食管裂孔疝修补术联合Nissen 胃底折叠术短期疗效分析[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(05): 512-517.
[6]	周艳, 李盈, 周小兵, 程发辉, 何恒正. 不同类型补片联合Nissen 胃底折叠术修补食管裂孔疝的疗效及复发潜在危险因素[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(05): 528-533.
[7]	王小琴, 汪丽, 崔建英. 无张力疝修补术治疗慢性肾功能衰竭合并腹股沟疝患者的疗效[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(05): 538-542.
[8]	王亚岚, 倪婧, 余世庆, 陶银花, 张荣. 尼达尼布抗纤维化治疗特发性肺纤维化的耐受性和疗效预测因素分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 750-755.
[9]	詹济玮, 蔡柳春, 温琼娜, 郭石生, 温春妹, 温鹤明. 布地格福联合噻托溴铵治疗AECOPD 的临床分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 823-826.
[10]	梁艳娉, 列诗韵, 王艺穗, 吴晓瑛, 林颖. 基于内镜操作细节记录系统构建胃底静脉曲张内镜下组织胶注射术的标准化管理方案[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(05): 705-709.
[11]	陈杰, 武明胜, 李一金, 李虎, 向源楚, 荣新奇, 彭健. 低位直肠癌冷冻治疗临床初步分析[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(06): 494-498.
[12]	史彬, 司远. 益气和络方联合缬沙坦治疗气阴两虚兼血瘀证IgA 肾病的疗效观察[J/OL]. 中华肾病研究电子杂志, 2024, 13(06): 306-312.
[13]	韩俊岭, 王刚, 马厉英, 连颖, 徐慧. 维生素D 联合匹维溴铵治疗腹泻型肠易激综合征患者疗效及对肠道屏障功能指标的影响研究[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 560-564.
[14]	阳跃, 庹晓晔, 崔子豪, 欧阳四民, 林海阳, 胡景宇, 胡银, 李涛, 赵景峰, 郝岱峰, 冯光. 改良“阅读者”皮瓣修复骶尾部压疮的疗效[J/OL]. 中华临床医师杂志(电子版), 2024, 18(08): 751-755.
[15]	克地尔牙·马合木提, 胡波, 杨琼, 闫素, 胡岚卿, 高沛沛, 姚恩生. 依达拉奉右莰醇对急性脑梗死后认知功能障碍的疗效观察[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(05): 459-466.

阅读次数

全文

摘要

选择文件类型/文献管理软件名称

选择包含的内容

Therapeutic Effects of Transcervical Resection of Polyp Combined With Marvelon on Endometrial Polyps

模态框（Modal）标题

选择文件类型/文献管理软件名称

选择包含的内容

Therapeutic Effects of Transcervical Resection of Polyp Combined With Marvelon on Endometrial Polyps