低分子肝素和丹参溶液联合治疗早发型重度子痫前期的疗效分析

doi:10.3877/cma.j.issn.1673-5250.2012.05.022

中华妇幼临床医学杂志(电子版) ›› 2012, Vol. 08 ›› Issue (05) : 629 -631. doi: 10.3877/cma.j.issn.1673-5250.2012.05.022

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低分子肝素和丹参溶液联合治疗早发型重度子痫前期的疗效分析

吴萍¹^,^*^,^*(

), 余祯秀¹, 谭晓燕¹

^1. 404100　重庆，重庆三峡中心医院妇产科

收稿日期:2012-06-02 修回日期:2012-09-17 出版日期:2012-10-01
通信作者: 吴萍

Curative Effects of Low Molecular Weight Heparin and Salvia Miltiorrhiza on Early Onset Severe Preeclampsia

Ping WU¹(), Zhen-xiu YU¹, Xiao-yan TAN¹

^1. Department of Obstetrics and Gynecology, Chongqing Three Gorges Central Hospital, Chongqing 404100, China

Received:2012-06-02 Revised:2012-09-17 Published:2012-10-01
Corresponding author: Ping WU
About author:
(Corresponding author: WU Ping, Email: 120803130@qq.com)

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目的

分析低分子肝素和丹参溶液治疗早发型重度子痫前期的疗效。

方法

选择2010年6月至2011年12月于本院就诊的75例早发型重度子痫前期患者为研究对象，并随机分为A组(n＝18,常规治疗)，B组(n＝20,常规治疗＋皮下注射低分子肝素)，C组(n＝19,常规治疗＋静脉滴注丹参溶液)和D组(n＝18,常规治疗＋皮下注射低分子肝素＋静脉滴注丹参溶液)(本研究遵循的程序符合本院人体试验委员会所制定的伦理学标准，得到该委员会批准，分组征得受试对象本人的知情同意，并与之签署临床研究知情同意书)。

结果

A组产后7 d出院率、转氨酶升高和低蛋白血症发生率与其余3组比较，差异均有统计学意义(P<0.05)。D组平均延长胎龄、平均出生体重与其余3组比较，差异也有统计学意义(P<0.05)。

结论

低分子肝素和丹参溶液联合治疗早发型重度子痫前期可延长孕龄、促进胎儿成长，改善母婴结局。

关键词: 低分子肝素, 丹参, 早发型重度子痫前期

Objective

To analysis the curative effects of low molecular weight heparin and salvia miltiorrhiza on early onset severe preeclampsia.

Methods

From June 2010 to December 2011, 75 women with early onset severe preeclampsia were included in the study, and divided into group A(n=18, routine treatment), group B(n=20, routine treatment + low molecular weight heparin), group C(n=19, routine treatment + salvia)and group D(n=18, routine treatment+ low molecular weight heparin+ salvia). The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Chongqing Three Gorges Central Hospital.Informed consent was obtained from each patients.

Results

There were significant differences in the postpartum 7 d hospital discharge rate, incidence of elevated liver enzymes and hypoproteinemia between group A and the other groups(P<0.05). The prolong average gestational age and birth weight in group D was obviously higher than that of the other groups.

Conclusions

Low molecular weight heparin combined with salvia on early onset severe preeclampsia contributes to the improvement of materno-fetal outcomes.

Key words: low molecular heparin, salvia, early onset of severe preeclampsia

表1 4组患者并发症发生情况比较[n(%)]

Table 1 Comparison of complications among four groups [n(%)]

组别	n	肺水肿	心力衰竭	脑出血	胎盘早剥	产后出血	转氨酶升高	低蛋白血症	视觉障碍
A组	18	2(11.11)	1(5.55)	0(0.00)	2(11.10)	3(16.67)	16(88.90)	17(94.44)	5(27.78)
B组	20	0 (0.00)	0(0.00)	0(0.00)	0 (0.00)	3(15.00)	12(60.00)	12(60.00)	4(20.00)
C组	19	0 (0.00)	0(0.00)	1(5.26)	0 (0.00)	2(10.53)	12(63.16)	10(52.63)	3(15.79)
D组	18	1 (5.55)	0(0.00)	0(0.00)	1 (5.55)	3(16.67)	10(55.56)	9(50.00)	3(16.67)

表1 4组患者并发症发生情况比较[n(%)]

Table 1 Comparison of complications among four groups [n(%)]

组别	n	肺水肿	心力衰竭	脑出血	胎盘早剥	产后出血	转氨酶升高	低蛋白血症	视觉障碍
A组	18	2(11.11)	1(5.55)	0(0.00)	2(11.10)	3(16.67)	16(88.90)	17(94.44)	5(27.78)
B组	20	0 (0.00)	0(0.00)	0(0.00)	0 (0.00)	3(15.00)	12(60.00)	12(60.00)	4(20.00)
C组	19	0 (0.00)	0(0.00)	1(5.26)	0 (0.00)	2(10.53)	12(63.16)	10(52.63)	3(15.79)
D组	18	1 (5.55)	0(0.00)	0(0.00)	1 (5.55)	3(16.67)	10(55.56)	9(50.00)	3(16.67)

表2 4组围生儿情况比较[n(%)]

Table 2 Comparison of perinatal infants outcome among four groups [n(%)]

组别	围生儿总数	胎儿窘迫	新生儿窒息	新生儿呼吸窘迫	平均延长胎龄(d)	平均出生体重(g)
A组	20	4(20.00)	12(60.00)	13(65.00)	4.7±2.1	2063.2±48.3
B组	22	1 (4.55)	8(36.36)	10(45.45)	5.8±3.4	2135.2±39.5
C组	21	2 (9.52)	6(28.57)	8(38.10)	6.2±3.6	2164.7±41.6
D组	21	1 (4.76)	7(33.33)	8(38.10)	10.3±4.5	2281.3±47.1

表2 4组围生儿情况比较[n(%)]

Table 2 Comparison of perinatal infants outcome among four groups [n(%)]

组别	围生儿总数	胎儿窘迫	新生儿窒息	新生儿呼吸窘迫	平均延长胎龄(d)	平均出生体重(g)
A组	20	4(20.00)	12(60.00)	13(65.00)	4.7±2.1	2063.2±48.3
B组	22	1 (4.55)	8(36.36)	10(45.45)	5.8±3.4	2135.2±39.5
C组	21	2 (9.52)	6(28.57)	8(38.10)	6.2±3.6	2164.7±41.6
D组	21	1 (4.76)	7(33.33)	8(38.10)	10.3±4.5	2281.3±47.1

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Curative Effects of Low Molecular Weight Heparin and Salvia Miltiorrhiza on Early Onset Severe Preeclampsia

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Curative Effects of Low Molecular Weight Heparin and Salvia Miltiorrhiza on Early Onset Severe Preeclampsia