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中华妇幼临床医学杂志(电子版) ›› 2011, Vol. 07 ›› Issue (05) : 493 -495. doi: 10.3877/cma.j.issn.1673-5250.2011.05.024

综述

STOX1与子痫前期关系的研究进展
刘倩   
  1. 518101 深圳,广东医学院附属深圳市第八人民医院
  • 出版日期:2011-10-01

Research Progress of the Relationship Between STOX1 and Preeclampsia

Qian LIU   

  1. Department of Obstetrics, Shenzhen Bao'an People's Hospital Affiliated to Guangdong Medical College, Shenzhen 518101, Guangdong Province, China
  • Published:2011-10-01
引用本文:

刘倩. STOX1与子痫前期关系的研究进展[J]. 中华妇幼临床医学杂志(电子版), 2011, 07(05): 493-495.

Qian LIU. Research Progress of the Relationship Between STOX1 and Preeclampsia[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2011, 07(05): 493-495.

STOX1是新近发现的一个子痫前期(PE)母系印迹基因,位于人类染色体10q22,参与调节绒毛外滋养细胞的多倍体化过程。其功能缺失所致的细胞滋养细胞间质侵入过浅和受限,在胎盘形成和PE发病中具有重大作用。

STOX1 is a newly discovered maternally imprinted gene of preeclampsia (PE) located on human chromosome 10q22. A defect in polyploidization preceding incomplete invasion of extravillus trophoblast as caused by STOX1 dysfunction therefore seems to play an important role in the formation of the placenta and the pathogenesis of PE.

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