实施前瞻性队列研究，探讨胎儿永久性右脐静脉(persistent right umbilical vein, PRUV)的产前诊断及临床预后。

选择2008年1月至2010年1月在四川大学华西第二医院对中、低危妊娠孕妇，采用超声系统筛查胎儿永久性右脐静脉及其他结构异常及胎儿染色体检查(本研究程序符合本院人体试验委员会制定的伦理学标准，得到该委员会批准，并与受试对象签署临床研究知情同意书)。

产前超声诊断胎儿永久性右脐静脉为20例(20/7692, 0.26%)。其中，永久性右脐静脉合并其他结构异常胎儿为4例(20%，4/20)，孤立性永久性右脐静脉为16例(80%，16/20)。14例孤立性永久性右脐静脉胎儿产后生长发育正常。行胎儿染色体检查为9例，其中21-三体综合征为1例，且合并严重结构异常。

产前超声诊断胎儿永久性右脐静脉时，应对胎儿进行系统筛查，以排除严重胎儿结构异常。80%胎儿永久性右脐静脉是孤立性的，妊娠结局良好。胎儿永久性右脐静脉合并多种胎儿结构异常时，应进行胎儿染色体检查。

To conduct a prospective study to evaluate prenatal ultrasound diagnosis and prognosis of fetus with persistent right umbilical vein(PRUV).

From January 2008 to January 2010, middle-and low-risk pregnant women were prospectively evaluated at the Department of Ultrasound in West China Second University Hospital of Sichuan University about persistent right umbilical vein, additional malformation and karyotype analysis. Informed consent was obtained from all participants.

Persistent right umbilical vein was detected in 20 fetuses of 7692 pregnancies(0.26%). 4 of them had additional malformation, 16 had no isolated persistent right umbilical vein, 14 fetuses were normal and healthy at birth. Chromosomal defects were including trisomy 21 diagnosed in 1 of 9 cases that accepted karyotype examination.

The sonographic finding of persistent right umbilical vein is an indication for conducting extensive detailed anatomic survey to ruled out major congenital malformations. In about 80% of persistent right umbilical vein is an isolated finding with favorable outcome. Persistent right umbilical vein fetus with additional sonographic abnormalities, which should be advised to accept karyotype analysis.