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中华妇幼临床医学杂志(电子版) ›› 2010, Vol. 06 ›› Issue (01) : 65 -67. doi: 10.3877/cma.j.issn.1673-5250.2010.01.125

综述

阴离子交换蛋白2与肿瘤
王思义, 张建华   
  1. 重庆 400016,重庆医科大学妇产科
  • 出版日期:2010-02-01

Anion Exchanger 2 and Tumor

Si-yi WANG, Jian-hua ZHANG   

  1. Department of Obstetrics and Gynecology, Chongqing Medical University, Chongqing 400016, China
  • Published:2010-02-01
引用本文:

王思义, 张建华. 阴离子交换蛋白2与肿瘤[J/OL]. 中华妇幼临床医学杂志(电子版), 2010, 06(01): 65-67.

Si-yi WANG, Jian-hua ZHANG. Anion Exchanger 2 and Tumor[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2010, 06(01): 65-67.

阴离子交换蛋白(anion exchanger, AE) 2在正常人体多重组织中表达,是一种多功能嵌膜蛋白,最初在红细胞膜上被鉴定。其主要功能是转运一价阴离子,生理条件下以极快速率进行Cl/HCO3交换。近年来发现其在某些肿瘤中表达明显异常,可能与肿瘤的发生、发展密切相关,并可能成为肿瘤疫苗治疗的重要靶位。

Anion exchanger (AE)2 expressed on many tissue of human beings. It is a versatile embedded membrane proteins, and was identified on the red blood cell membrane initially. The main function of anion exchanger 2 is to transfer anion of one price, and to exchange Cl-/HCO3 quickly under physiological conditions. In recent years, abnormal expressions of anion exchanger 2 on some tumors were found, and it may be closely related to the occurrence and development of tumors, and may become an important target site of tumor vaccine therapy.

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