探讨三维适形放射治疗(three-dimensional conformal radiation therapy, 3DCRT)＋介入化疗治疗中、晚期宫颈癌的疗效。

2006年5月至2007年5月选取80例在本院确诊为Ⅱ_B～Ⅲ期的宫颈癌患者为研究对象，将其随机分为试验组(n＝40,三维适形放疗＋介入化疗)和对照组(n＝40,三维适形放疗＋静脉化疗) (研究遵循程序符合本院人体试验委员会制定的伦理学标准，得到该委员会批准，分组征得患者知情同意，并与之签署临床研究知情同意书)，比较两组疗效、不良反应率和程度，并随访2年以上。

试验组患者完全缓解(complete remission, CR)率、2年生存率均高于对照组(85.0% vs. 77.5%, 87.5% vs. 75.0%)，两组比较，差异有显著意义(P<0.05)；骨髓抑制率、胃肠道系统不良反应率及严重程度明显低于对照组，两组比较，差异有显著意义(P<0.05)；泌尿系统不良反应率两组比较，差异无显著意义(P＝1.107)。

三维适形放疗＋介入化疗是治疗中、晚期宫颈癌的有效方法，不良反应程度轻，疗效高，临床上值得推广应用。

To study the efficacy of three-dimensional conformal radiation therapy(3DCRT) combined with interventional chemotherapy for intermediate and advanced cervical cancer.

From March 2006 to May 2007, 80 women patients with cervical cancer at Ⅱ_B-Ⅲ stage were randomly divided into experimental group(n=40) which received three-dimensional conformal radiation therapy combined with interventional chemotherapy and control group(n=40) which received three-dimensional conformal radiation therapy combined with intravenous chemotherapy. Efficacy and side effects were compared between two groups, and follow-up more than 2 years. Informed consent was obtained from all participates.

Complete remission(CR) rate and 2-year survival rate of experimental group were significantly higher than those of control group (85.0% vs. 77.5%, 87.5% vs. 75.0%) (P<0.05). Side effects of gastrointestinal tract and myelosuppression were less serious than those of control group(P<0.05). There had no significant differences in side effects of urinary system between two groups (P=1.107).

Three-dimensional conformal radiation therapy combined with interventional chemotherapy could improve the clinical efficacy with less side effects. It is an effective treatment for intermediate and advanced cervical cancer.