通过检测不孕妇女宫颈细胞因子白细胞介素 (interleukin, IL)–1β、白细胞介素–2、白细胞介素–6和肿瘤坏死因子(tumor necrosis factor，TNF)–α的水平，探讨宫颈细胞因子白细胞介素–1β、白细胞介素–2、白细胞介素–6、肿瘤坏死因子–α的水平与不孕妇女支原体感染的相关性。

选取2005年4月至2005年12月在佛山市第一人民医院妇产科就诊的85例不孕患者为研究对象。根据支原体培养结果，将其分为支原体阳性组(n＝44)与支原体阴性组(n＝41)(分组征得患者本人的知情同意)，采用放射免疫分析法分别检测两组患者宫颈细胞因子白细胞介素–1β、白细胞介素–2、白细胞介素–6、肿瘤坏死因子–α的水平。

支原体阳性组与支原体阴性组白细胞介素–1β和肿瘤坏死因子–α的表达比较，差异有显著意义(P＝0.001，OR＝15.678；P＝0.001，OR＝1.76E＋010)；两组白细胞介素–2的表达比较，差异无显著意义(P>0.05)。宫颈黏液中未检测出白细胞介素–6。

生殖道支原体感染可引起宫颈细胞因子白细胞介素–1、肿瘤坏死因子–α水平提高。

To discuss the relationship between genital mycoplasma infection on infertility women and cytokine level by detecting the cervical cytokine of interleukin(IL)-1β, interleukin-2, interleukin-6, and tumor necrosis factor (TNF)-α.

From April 2005 to December 2005, 85 cases recruited in the Department of Obstetrics and Gynecology, First People's Hospital of Foshan, were divided into 2 groups according to the mycoplasm culture results, mycoplasma positive group(n=44) and mycoplasma negative group(n=41). Informed consent was obtained from all patients. The expression of interleukin-1β, interleukin-2, interleukin-6, and tumor necrosis factor-α of cervical mucus were detected by the radioimmunity method.

Compared with the mean of cytokine expression of cervical mucus between mycoplasma positive group and mycoplasma negative group, there were significant differences of interleukin-1β (P=0.001, OR=15.678) and tumor necrosis factor-α (P=0.001, OR=1.76E+ 010), and there was no significant difference of interleukin-2 (P>0.05). Interleukin-6 did not being detected in cervical mucus.

The genital mycoplasma infection can cause the raise of the cervical cytokine level of interleukin-1β and tumor necrosis factor-α.