探讨尿4种微量蛋白在妊娠肾损伤的早期临床诊断价值。

采用速率散射比浊法对正常妊娠产妇165例、妊高征45例和非孕对照40例的尿4种微量蛋白MA、TRF 、IgG和A₁M进行检测。

与对照组比较，早孕组尿4种微量蛋白差异无显著意义(P>0.05)；中孕组中MA、TRF有明显升高，差异有显著意义(P<0. 001)，其余无明显改变；晚孕组和妊高征组尿4种微量蛋白均有明显升高，差异有显著意义(P<0.001)。

尿中4种蛋白检测可以作为晚期妊娠肾损伤的早期诊断的灵敏指标，对肾小球或肾小管损伤及病情发展的判断、预后等也有一定临床意义。

To study the early diagnosis value of four uromicroproteins on renal injuries during pregnancy.

α₁-microalbumin(MA), transferring(TRF), IgG and(α₁-microglobulin(A₁M)in the urine samples of 165 cases of pregnant women, 45 cases of patients with gestational hypertension and 40 cases of controls were detected by rate nephelometry.

The difference of the four uromicroproteins between early pregnancy group and control group was not significant(P>0. 05). Compared with the controls, the increases of MA and TRF in medium pregnancy group were obvious(P< 0. 001), and the four uromicroproteins in late pregnancy group and gestational hypertension group increased significantly(P<0. 001).

The four uromicroproteins in urine are early sensitive indicators in renal injuries during late pregnancy, and they have clinic significance in distinguishing the renal corpuscle or renal tubule damage when considering the development and prognosis of the disease.